The leading causes of maternal mortality in most Sub-Saharan countries include obstetric haemorrhage, eclampsia, sepsis, and complications from unsafe abortions. On the other hand, conditions largely responsible for the death of infants and children include preterm birth complications, pneumonia, sepsis, infections, and others. If implemented, certain key innovative interventions can go a long way in drastically reducing the unacceptable maternal and child mortality rates in Sub-Saharan Africa.